David Aylor
Bio
We study how genetic variation controls complex traits, susceptibility to disease, and individual molecular biology. Most prevalent human diseases, most agriculturally important traits, and evolutionary fitness are complex traits, which means they are influenced by a combination of multiple genetic and environmental factors. A long-standing goal in the field is to identify quantitative trait loci (QTL) – genetic variants that influence complex traits. Discovering these relationships is challenging because the individual factors each have small effects, and because genetic variants often interact with the environment (GxE) or other genes (epistasis). Figuring out how these variants change the function of cells or molecules has been even more difficult. Understanding these genetic mechanisms will enable the translation of model organism research to humans and uncover new principles of genetics and genome science. We develop and apply systems genetics approaches that enable us to discover QTL and reveal their mechanisms.
Publications
- A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes , AMERICAN JOURNAL OF HUMAN GENETICS (2022)
- Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters , NEUROENDOCRINOLOGY (2022)
- A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy , FRONTIERS IN NEUROSCIENCE (2021)
- Age and Genetic Background Modify Hybrid Male Sterility in House Mice , GENETICS (2020)
- Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains , MAMMALIAN GENOME (2020)
- Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains , GENETICS (2019)
- Animal models of endocrine disruption , BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2018)
- Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius , SCIENTIFIC REPORTS (2018)
- Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse , MAMMALIAN GENOME (2018)
- The NIEHS TaRGET II Consortium and environmental epigenomics , Nature Biotechnology (2018)