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Fabienne Poulain, University of South Carolina
January 22 @ 1:30 pm - 2:30 pm
Destroy to build: trans-axonal degenerative signaling shapes neural circuits during development
Fabienne Poulain, Assistant Professor of Biological Sciences, University of South Carolina
Abstract
Precise wiring of neuronal circuits is crucial for brain connectivity and function. A major challenge in neuroscience is to understand how these connections are properly established, and how errors in this wiring process may lead to disorders. As they develop, neurons extend axons that are guided along defined paths towards their target by attractive and repulsive cues present in the environment. In addition to this guidance process, pruning mechanisms eliminate axons that have deviated from the right path, thereby ensuring the accuracy of circuit formation. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Taking advantage of the unique accessibility and transparency of the zebrafish embryo, our studies demonstrate that axon degeneration is precisely regulated in vivo and constitutes an essential developmental process for brain wiring.
Join us on Monday, January 22 at 1:30 PM in Stephens Room (3503 Thomas Hall) and ZOOM for the Genetics and Genomics Seminar Series. Link: https://ncsu.zoom.us/j/99465646573?pwd=SWdOMkQwV2xpRXdJanRsODZiOWFsQT09
If you are interested with meeting with Fabienne Poulain, please contact host Kurt Marsden (kcmarsde@ncsu.edu)