Brian Diekman
BD
Associate Professor
[email protected]Bio
Dr. Diekman has established a research laboratory that utilizes regenerative medicine technologies to develop novel therapeutic approaches for osteoarthritis. One goal of the lab is to use engineered cartilage tissue as a model system to understand the mechanisms by which aging contributes to cartilage dysfunction and to screen for drugs that prevent cartilage dysfunction. The lab also uses genome editing of stem cells to investigate the genetic risk factors for osteoarthritis. In addition to experiments with cultured cells, work with rodent models allows the lab to test the feasibility of interventions designed to increase the regenerative capacity of cartilage tissue after injury.
Publications
- Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types , bioRxiv (Cold Spring Harbor Laboratory) (2026)
- Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types , PLoS Genetics (2026)
- Human hip osteoarthritis–associated Chadl variant induces intervertebral disc degeneration in mice , bioRxiv (Cold Spring Harbor Laboratory) (2026)
- MDL ‐800–Induced Sirtuin 6 Activation Decreases Age‐Associated Osteoarthritis in Mice , Arthritis & Rheumatology (2026)
- Osteoarthritic synovial fibroblasts drive inflammatory responses and impair chondrocyte function in response to a fibronectin matrikine , Osteoarthritis and Cartilage (2026)
- Sex differences in senescence burden within human osteoarthritic synovial fibroblasts , bioRxiv (Cold Spring Harbor Laboratory) (2026)
- ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain , Aging Cell (2026)
- Biomarkers of aging as it relates osteoarthritis: we can’t improve what we can’t measure , Connective Tissue Research (2025)
- GENE EXPRESSION, RNA SPLICING, AND CHROMATIN ACCESSIBILITY QUANTITATIVE TRAIT LOCI IDENTIFY PUTATIVE OSTEOARTHRITIS RISK GENES , Osteoarthritis and Cartilage (2025)
- Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction , GeroScience (2025)