Kurt Selle
Director, Operations
[email protected]Bio
Dr. Kurt Selle is the Director of Operations at BTEC and is responsible for the technical and operational oversight of cell line development, small scale and large scale fermentation activities at BTEC. He originally joined BTEC in 2020 as a senior scientist supporting the Accelerated Innovation in Manufacturing Biologics (AIM-Bio) program. Previously, he was a lead scientist and manager at Locus Biosciences and was responsible for establishing a synthetic biology platform for early drug development, intellectual property generation, and clinical readiness of a first-in-class recombinant phage biologic. His research experience bridges the disciplines of bacteriology, phage and CRISPR biology, molecular genetics, biotechnology, and high-throughput data technologies, applying those competencies across probiotic, pathogenic, and fermentative bacteria towards understanding fermentation microbiology and improving human-microbe interactions.
Courses
Publications
- Applications of designer phage encoding recombinant gene payloads , Trends in biotechnology (2023)
- Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus , FEMS Microbiology Letters (2019)
- Short communication: Transcriptional response to a large genomic island deletion in the dairy starter culture Streptococcus thermophilus , Journal of Dairy Science (2019)
- Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus , Frontiers in Microbiology (2017)
- CRISPR-based screening of genomic island excision events in bacteria , Proceedings of the National Academy of Sciences (2015)
- Harnessing CRISPR–Cas systems for bacterial genome editing , Trends in Microbiology (2015)
- JFS Special Issue: 75 years of advancing food science, and preparing for the next 75 CRISPR-based technologies and the future of food science , Journal of Food Science (2015)
- Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri , Microbiology (2015)
- SIGNR3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis , The EMBO Journal (2015)
- Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality , Molecular Cell (2014)