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Alex Marand, University of Michigan
February 26 @ 1:30 pm - 2:30 pm
Exploration of cis-regulatory diversity in extant Zea mays
Alex Marand, Assistant Professor of Molecular, Cellular, and Developmental Biology at University of Michigan
Abstract
Each cell of a multicellular organism generally contains the same DNA sequence. Yet, a single organism is composed of hundreds to thousands of highly diverse and functionally unique cell types. This diversification is largely the result of differential gene regulation; distinct cell types express unique sets of genes that encode their identity and dictate their functions. At the forefront of gene regulation are cis-regulatory elements that control “when” and “where” a gene is expressed. Mutations within CREs can perturb the native pattern and magnitude of gene expression and result in drastic molecular, cellular, and morphological phenotypes, including developmental defects in plants and diseases in humans. Until recently, it has been impossible to profile active CREs from diverse cell types at scale. I will discuss new efforts to chart chromatin accessibility variation within and across Zea mays at the level of individual cells as a source of phenotypic innovation.
Join us on Monday, February 26 at 1:30 PM in Stephens Room (3503 Thomas Hall) and ZOOM for the Genetics and Genomics Seminar Series.
Register to attend virtually via Zoom.
No registration is required to attend In-Person
If you are interested with meeting with Alex Marand, please contact host Joe Gage (jlgage@ncsu.edu).