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Parul Johri, UNC Chapel Hill
September 9 @ 1:30 pm - 2:30 pm
Jointly modeling the effects of evolutionary processes on genomic variation
Parul Johri, Assistant Professor of Biology and Genetics at UNC Chapel Hill
Abstract
Population genomic inference currently assumes that all segregating mutations are neutral and does not account for the effects of selection across the genome, which is problematic when modeling genomic variation in species with compact genomes (i.e., those with a high density of protein-coding and regulatory regions) where natural selection is pervasive. We develop statistical and computational methods that simultaneously account for the effects of selection jointly with other evolutionary processes to make accurate evolutionary inferences using sequence variation from natural populations. As most pathogenic species tend to have highly compact genomes and experience strong bouts of selection and drastic repeated bottlenecks, I discuss how our methodological advances and recent theoretical efforts will be important to uncovering their population and selective history.
Join us on Monday, September 9 at 1:30 PM in Stephens Room (3503 Thomas Hall) and ZOOM for the Genetics and Genomics Seminar Series. REGISTER to attend Zoom: https://ncsu.zoom.us/meeting/register/tJUufu2rrDwuGtMzQ2ivMoBl4_LJ-eSGAZ4q
If you are a student or postdoc who would like to meet with Dr. Johri please sign up here: https://docs.google.com/spreadsheets/d/1_5-iHgJi8ei3uFBg1d5k1md8yX-PTzIJy7hEg7RwKa0/edit?gid=647453152#gid=647453152
If you are interested with meeting with Parul Johri, please contact host David Rasmussen (drasmus@ncsu.edu).
