Preventing and promoting crossovers between homologous chromosomes

Abstract

“To discuss my lab’s research on meiotic and mitotic crossovers in Drosophila, I decided to resurrect The Bloom Syndrome Helicase Trilogy, modeled on The Dark Knight Trilogy. Part I: Blm is introduced as a hero that saves broken chromosomes from making detrimental mitotic crossovers. Part II: Blm is recast as the villain because meiotic chromosomes need to make crossovers to segregate. To do this, a novel complex evolved to thwart Blm. Part III: Blm was never really the villian. In fact, Blm has a critical role in making meiotic recombination meiotic. I will finish with a sequel about mitotic crossovers in a site that has >200 kb of a tandem octamer repeat within the intron of a > 2 Mb myosin gene that resides in heterochromatin.”

Join us on Monday, September 21 at 1:30 PM in Stephens Room (3503 Thomas Hall) and ZOOM for the Genetics and Genomics Seminar Series. This event will be held in person in Stephens Room (3503 Thomas Hall) and on Zoom.

Attend via Zoom:

Please contact co-hosts Jeff Yoder ([email protected]) and Jennifer Ocasio Adorno ([email protected]) with any question.