Bio

After graduating from the Veterinary School of Nantes, Dr Guilluy completed his PhD under the supervision of Pierre Pacaud and Gervaise Loirand at the University of Nantes, where he identified key signaling molecules that control contractility in smooth muscle cells and play a role in vascular diseases. He then performed his postdoctoral training in the laboratory of Keith Burridge at UNC Chapel Hill and investigated how mechanical tension regulates cytoskeletal organization and nuclear functions. Before he joined North Carolina State University, Dr Guilluy led his research team at the Institute for Advanced Biosciences (Inserm – France), where he began studying how nuclear structure and dynamics control cellular processes in physiology and diseases.

Publications

• Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding , bioRxiv (Cold Spring Harbor Laboratory) (2025)
• Calcium waves and nuclear tension changes coordinate mechanical stress dissipation in locally folded epithelia , iScience (2025)
• ECM stiffness regulates lung fibroblast survival through RasGRF1-dependent signaling , Journal of Biological Chemistry (2025)
• Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation , eLife (2023)
• SUN2 regulates mitotic duration in response to extracellular matrix rigidity , Proceedings of the National Academy of Sciences (2022)
• Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System , Cellular and Molecular Gastroenterology and Hepatology (2017)
• Lysyl oxidase like-2 (LOXL2) regulates endothelial mechanotransduction and 3D vascular morphogenesis through scaffolding of basement membrane , Archives of Cardiovascular Diseases Supplements (2017)
• Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface , Current Opinion in Cell Biology (2016)
• Focal adhesions, stress fibers and mechanical tension , Experimental Cell Research (2015)
• Nuclear mechanotransduction: Forcing the nucleus to respond , Nucleus (2015)