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Audrey Gasch, University of Wisconsin – Madison
October 16, 2023 @ 1:30 pm - 2:30 pm
Cellular impacts of chromosomal aneuploidy in disease, aging, and evolution
Audrey Gasch, Ph.D., Professor of Genetics, Director of the UW-Madison Center for Genomic Science Innovation
Abstract
Aneuploidy, the state in which cells carry an abnormal number of one or more chromosomes, is associated with major defects during mammalian development. Yet aneuploidy is frequent in cancers, and chromosome amplification is an important route to rapid phenotypic evolution in multiple organisms. Why aneuploidy is toxic in some situations but beneficial in others remains a mystery, in part because the cellular consequences of aneuploidy remain poorly understood. This talk will present mechanistic insights from studies of wild isolates of budding yeast Saccharomyces cerevisiae, which are frequently aneuploid and much more tolerant than laboratory strains. Cellular mechanisms uncovered have major implications for aging in Down syndrome and cell-cycle disruption in cancer cells.
Join us on Monday, October 16 in Stephens Room (3503 Thomas Hall) and ZOOM for the Genetics and Genomics Seminar Series. Link: https://ncsu.zoom.us/j/91741454918?pwd=U0drVUpPdGJiSXVpcnVUZDNwaHVUZz09
