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CANCELED (will be rescheduled) Dr. Trisha Wittkopp, University of Michigan
September 26 @ 1:30 pm - 2:30 pm
This event has been canceled and will likely be rescheduled in the Spring.
Molecular and evolutionary processes generating variation in gene expression
Trisha Wittkopp, Ph.D., Sally L. Allen Professor of Ecology & Evolutionary Biology and Molecular, Cellular, and Developmental Biology at University of Michigan
Genetic variation affecting gene expression is wide-spread within and among species. This variation reflects the combined actions of mutation introducing new genetic variants and selection eliminating deleterious ones. Comparative studies of gene expression in fruit flies, yeast, plants, and mice have shown that the relative contributions of cis- and trans-acting variants to expression differences change over evolutionary time, indicating that selection has different effects on cis- and trans-regulatory variants. To better understand the reasons for this now widely observed pattern, we have been systematically studying the effects of mutation and selection on expression of the TDH3 gene of the baker’s yeast Saccharomyces cerevisiae. This work has revealed differences between cis- and trans-regulatory mutations in their frequency, effects, and dominance. Differences in pleiotropy are also generally assumed to exist between cis- and trans-regulatory that affect their evolutionary fate, but have been difficult to measure. In this talk, I will discuss how newly arising cis- and trans-regulatory mutations affecting expression of this focal gene are structured within the regulatory network, their pleiotropic effects on expression of all other genes in the genome, and how these pleiotropic effects influence fitness.
The GGA Seminar Series is held In-Person and on Zoom: https://ncsu.zoom.us/j/99920963547?pwd=alRnK21UMDVHRVgxT2tWa3JoK1pPdz09